Depends how you frame it. Canary Wharf is the largest skyscraper cluster in London and sits directly under the flight path about 4 kilometres away. That would be like if the largest skyscraper cluster in Toronto was in the southern Portlands, directly underneath the approach path for YTZ.
YTZ doesn't really have anything under it's flight paths, the areas with the largest impacts.
Also, London City has the closest private residential properties just 160 metres from the runway - comparatively, the closest residential properties to YTZ are about 500 metres away!:
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It's not technically closer to the Downtown of London, but definitely operates in a much denser environment and is less removed from it's surroundings than YTZ is.
YTZ benefits by being on an island in the middle of the lake, the location means it sits about half a kilometre from basically any other use, which means a lot of it's worst impacts are mitigated.