Obviously they aren't going to replace every single one, but I really do believe they will at least take ONE of those spaces. I work for Winners, the business model is insanely scalable that it's almost scary. They don't care about location at all because they can turn a profit so easily, the customers love "The Thrill Of The Find". There are numerous areas that have multiple Winners in close proximity to one another, or a Winners in the same mall or close in distance to a Marshalls (Heartland, Vaughan Mills, Yonge and Dundas, Stock Yards Village, Dufferin Mall, Markville, RioCan Colossus/Woodbridge...) With any other business, that'd be an insane thing to do, but the off-price model works so well that it doesn't matter...
All this to say, they have far fewer considerations to take with store openings than most businesses. They have taken advantage of anchor closings before like Sears and Target, and they're pretty hard to say no to if you have a big vacant space to fill... These are multi-million-dollar revenue stores. And I've never seen a Winners/Homesense/Marshalls close other than to relocate.